Gut microbiome as a response marker for pancreatic enzyme replacement therapy in a porcine model of exocrine pancreas insufficiency

Table 1 Decreased abundance in percent of bacterial genera in pancreatic duct-ligated Göttingen minipigs compared to PERT treated animals

Decreased bacterial genera	EPI		EPI + PERT		Δ	p	p_cor
Decreased bacterial genera	Med.	IQR	Med.	IQR	Δ	p	p_cor
Corynebacterium	0.127	0.137	0.041	0.066	− 65.25	0.024	0.179
Brachybacterium	0	0.049	0	0	− 64.41	0.009	1.725
Kocuria	0.053	0.086	0	0.043	− 65.75	0.009	0.862
Tessaracoccus	0	0.058	0	0	− 100	0.009	0.575
Bifidobacterium	0.191	0.089	0.051	0.051	− 68.98	0.009	0.431
Prevotella	2.420	0.855	1.895	1.036	− 26.95	0.024	0.172
Sphingobacterium	0	0.077	0	0	− 100	0.009	0.345
Chryseobacterium	0	0.147	0	0	− 100	0.009	0.288
Empedobacter	0	0.050	0	0	− 69.84	0.009	0.246
Wautersiella	0	0.287	0	0	− 96.75	0.043	0.285
Brevundimonas	0	0.104	0	0	− 100	0.009	0.216
Ralstonia	0	0.049	0	0	− 78.54	0.009	0.192
Comamonas	0.040	0.078	0	0	− 100	0.009	0.172
Parasutterella	0	0.047	0	0	− 80.91	0.043	0.275
Bilophila	0	0.042	0	0.019	− 53.39	0.009	0.157
Escherichia/Shigella	1.375	0.634	0.096	0.296	− 80.35	0.013	0.099
Acinetobacter	0.264	1.632	0.076	0.123	− 92.89	0.009	0.144
Enhydrobacter	0	0.047	0	0	− 71.62	0.009	0.133
Stenotrophomonas	0.090	0.067	0.043	0.027	− 61.57	0.043	0.266
Cloacibacillus	0.053	0.101	0	0.021	− 77.08	0.009	0.123
Caryophanon	0.053	0.182	0	0	− 97.26	0.009	0.115
Kurthia	0	0.045	0	0	− 100	0.009	0.108
Macrococcus	0	0.052	0	0	− 100	0.009	0.101
Pseudoramibacter	0.047	0.055	0	0.039	− 59.74	0.043	0.257
Acetanaerobacterium	0.047	0.010	0.043	0.048	− 37.61	0.009	0.096
Dialister	0.048	0.063	0.038	0.053	− 40.09	0.009	0.091
Selenomonas	0	0.055	0	0	− 100	0.009	0.086

Bacterial genera with a noteworthy reduced abundance after 28 days of PERT based on the Wilcoxon signed-rank test (α = 0.05) are listed
EPI: relative abundance in EPI affected pigs; EPI + PERT: relative abundance in EPI pigs after treatment; med.: median; IQR: interquartile range; Δ: relative change based on original mean abundance; p: p-value; p_cor: p-values corrected according Benjamini–Hochberg method
All values are in percent and genera are shown in taxonomic order

ISSN: 1475-2859