Table 1 Representative chemicals produced by B. subtilis

Riboflavin

B. subtilis 125

The deregulation of the rib operon and purine de novo synthesis pathway

4232 ± 34.42 mg/L

[50]

Menaquinone-7

B. subtilis 20-QT

Co-overexpression of tatAD-CD and qcrA-C

410 mg/L

[60]

Scyllo-Inositol

B. subtilis KU303

Deletion of iolABCDEF, iolHIJ, iolX and iolR, combined with the expression of IolG, IolW, IolT and PntAB

27.6 g/L

[61]

Hyaluronic acid

B. subtilis E168TH

Expression of hasA, tuaD, gtaB, glmU, glmM, glmS, and H6LHyal

19.38 g/ L

[64]

N-acetylglucosamine

B. subtilis 168 BNDR122

Deletion of nagP, gamP, gamA, gamR, nagA, nagB, ldh, alsRSD, pta, ackA, glcK, pckA, pyk, lacA and amyE, combined with the expression of GNAI

131.6 g/L

[67]

Amorphadiene

B. subtilis 1A1

Overexpression of dxs, idi and ads

20 mg/L

[96]

Poly-γ-glutamic acid

B. subtilis ZJU − 7

Optimizing culture conditions

101.1 g/L

[97]

Acetoin

B. subtilis CGMCC 13,141

Deletion of araR, bdhA and acoA

83.7 g/L

[98]

Shikimate

B. subtilis 168 CLC6-PYKA

Deletion of pykA and aroI

4.67 g/L

[99]

2,3-Butanediol

B. subtilis F9

Deletion of upp, acoA, bdhA, pta, and ldh, combined with the expression of alsS, alsD, budC, and udhA

103.7 g/L

[100]

Isobutanol

B. subtilis UL08

Deletion of alsS, ldh, pdhC and pgi, combined with the expression of zwf and udhA

6.12 g/L

[101]

Chondroitin

B. subtilis E168H

Expression of kfoC-kfoA and kfiC-kfiA, combined with the upregulation of tuaD

5.22 g /L

[102]

Heparosan

B. subtilis E168H

Expression of kfoC-kfoA and kfiC-kfiA, combined with the upregulation of tuaD

5.82 g/ L

[102]