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Fig. 2 | Microbial Cell Factories

Fig. 2

From: In vivo characterization of the activities of novel cyclodipeptide oxidases: new tools for increasing chemical diversity of bioproduced 2,5-diketopiperazines in Escherichia coli

Fig. 2

Diversity of CDOs. a A sequence similarity network was constructed with 1610 sequences homologous to CDOA-Snou11455, which are represented as nodes. Edges between nodes indicate sequence identity > 26.5%. The nodes corresponding to CDOA-Snou11455 and CDOA-Ndas43111 are shown in red. Nodes corresponding to CDOA subunits, for which the gene is associated in the genome with cdoB and cdps genes are shown in green. Salmon-coloured nodes correspond to CDOA subunits linked by an edge to CDOA subunits coloured in green or red. b Phylogenetic tree of 32 selected sequences of CDOA subunits (left panel) and CDOB subunits (right panel). The main product of the activity of the CDPS associated with the corresponding CDO in the biosynthetic gene cluster is indicated as cXX, X being one l-amino acid. Subunit names of CDOs of S. noursei ATCC 11455, S. monomycini NRRL B‐24309, S. varsoviensis NRRL B‐3589 and N. dassonvillei DSM 43111 are written in red. Clades encompassing subunits of CDOs of S. noursei ATCC 11455 and N. dassonvillei DSM 43111 are highlighted by rectangles coloured in yellow and blue, respectively. Subunit names of CDOs investigated in this study are coloured in green

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Microbial Cell Factories

ISSN: 1475-2859

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