Fig. 1

Activities of CDPSs and CDOs in biosynthetic pathways. The names of the final products of the pathways are indicated. Dashed arrows indicate hypothetical subsequent tailoring steps in the biosynthetic pathway. The activities of PcmA (CDPS) and PcmB/C (CDO) involved in purincyclamide biosynthesis are similar to those of GutA24309 and Gut(BC)24309, respectively, and purincyclamide is identical to guanitrypmycin A2-1 [11, 12]