Fig. 5

Extant mutants that were commonly more (a) or less (b) fit over the course of the cultivation in either fed-batch bioreactors, batch bioreactor, or shake flasks from 0 to 119 h for the fed-batch bioreactors and 0 h to 72 h for the batch bioreactor and shake flasks. As shown in Fig. 2b, the majority of population changes occurred before 72 h in fed-batch cultivations. Venn diagrams show the number of mutants common or unique between parameters tested