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Table 1 Comparison of BDO production using whey/lactose as substrate by different microorganisms

From: Efficient 2,3-butanediol production from whey powder using metabolically engineered Klebsiella oxytoca

Strain

Substrate

Method

Concentration (g/L)

Yield (g/g)

Productivity (g/L/h)

References

Bacillus polymyxa ATCC 1232

Cheese whey

Wild-type

5.5

0.25

0.03

[22]

K. pneumoniae NCIB 8017

Rennet whey permeate

Wild-type

7.5

0.46

0.08

[42]

K. oxytoca NRRL-13-199

Whey

Wild-type, adding 50 mM acetate

8.4

0.365

[30]

Enterobacter aerogenes 3889

Whey

Wild-type, using neutralized acid whey with 50 mM acetate

15.1

0.24

[23]

K. pneumoniae ATCC 13882

Whey

Wild-type, using unsterilized acid whey and adjusting pH to 6.5

19.3

0.32

[23]

Lactococcus lactis mL001

Residual whey permeate (lactose)

Deletion of ldh, ldhB, ldhX, pta, adhE, butBA, overexpression of bdh and lactose utilizing pathway in L. lactis MG1363

51

0.47

1.46

[32]

K. oxytoca PDL-K5

Whey powder

Deletion of pox, pta, frdA, ldhD, pflB in K. oxytoca PDL-0

65.5

0.44

2.73

This study

K. pneumoniae KG1

Lactose

Wild-type

4.38

0.33

0.365

[21]

K. oxytoca NRRL-B199 with nonviable cells of Kluyveromyces lactis CBS 683

Lactose

Wild-type, co-immobilization by adhesion of β-galactosidase in nonviable cells of K. lactis with K. oxytoca

14.3

0.29

0.80

[25]

K. oxytoca ATCC 8724

Lactose

Wild-type

32.49

0.207

0.861

[31]

K. oxytoca PDL-K5

Lactose

Deletion of pox, pta, frdA, ldhD, pflB in K. oxytoca PDL-0

74.9

0.43

2.27

This study