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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Deletion of pgi gene in E. coli increases tolerance to furfural and 5-hydroxymethyl furfural in media containing glucose–xylose mixture

Fig. 1

Flow of glucose and xylose carbon via central metabolic pathways in Escherichia coli. NADPH is generated via pentose phosphate (PP) pathway, tricarboxyic acid (TCA) cycle and membrane bound trans-hydrogenase. Xylose enters PP pathway at X5P step thus bypassing the NADP+ reducing steps catalyzed by glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase which are encoded by zwf and gnd, respectively. In Δpgi strain, pyr is generated via channeling of Gly-3-P and F-6-P from PP to Embden-Meyerhof-Paranas (EMP) pathway. Connecting intermediates are indicated with thin broken lines. Abbreviations are as follow: G-6-P, glucose-6-phosphate; X-5-P, xylulose-5-phosphate; gly-3-P, glyceraldehyde-3-phosphate; F-6-P, fructose-6-phosphate; PEP, phosphoenolpyruvate; Pyr, pyruvate; OAA, oxaloacetic acid

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Microbial Cell Factories

ISSN: 1475-2859

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