TY - JOUR AU - Becker, J. AU - Wittmann, C. PY - 2018 DA - 2018// TI - From systems biology to metabolically engineered cells-an omics perspective on the development of industrial microbes JO - Curr Opin Microbiol VL - 45 ID - Becker2018 ER - TY - JOUR AU - Hoffmann, S. L. AU - Jungmann, L. AU - Schiefelbein, S. AU - Peyriga, L. AU - Cahoreau, E. AU - Portais, J. C. AU - Becker, J. AU - Wittmann, C. PY - 2018 DA - 2018// TI - Lysine production from the sugar alcohol mannitol: design of the cell factory Corynebacterium glutamicum SEA-3 through integrated analysis and engineering of metabolic pathway fluxes JO - Metab Eng VL - 47 ID - Hoffmann2018 ER - TY - JOUR AU - Rohles, C. M. AU - Giesselmann, G. AU - Kohlstedt, M. AU - Wittmann, C. AU - Becker, J. PY - 2016 DA - 2016// TI - Systems metabolic engineering of Corynebacterium glutamicum for the production of the carbon-5 platform chemicals 5-aminovalerate and glutarate JO - Microb Cell Fact VL - 15 ID - Rohles2016 ER - TY - JOUR AU - Rohles, C. M. AU - Gläser, L. AU - Kohlstedt, M. AU - Giesselmann, G. AU - Pearson, S. AU - Campo, A. AU - Becker, J. AU - Wittmann, C. PY - 2018 DA - 2018// TI - A bio-based route to the carbon-5 chemical glutaric acid and to bionylon-6,5 using metabolically engineered Corynebacterium glutamicum JO - R Soc Chem Green Chem VL - 20 ID - Rohles2018 ER - TY - JOUR AU - Becker, J. AU - Rohles, C. M. AU - Wittmann, C. PY - 2018 DA - 2018// TI - Metabolically engineered Corynebacterium glutamicum for bio-based production of chemicals, fuels, materials, and healthcare products JO - Metab Eng VL - 50 ID - Becker2018 ER - TY - JOUR AU - Veras, H. C. T. AU - Campos, C. G. AU - Nascimento, I. F. AU - Abdelnur, P. V. AU - Almeida, J. R. M. AU - Parachin, N. S. PY - 2019 DA - 2019// TI - Metabolic flux analysis for metabolome data validation of naturally xylose-fermenting yeasts JO - BMC Biotechnol VL - 19 ID - Veras2019 ER - TY - JOUR AU - Peter, D. M. AU - Vogeli, B. AU - Cortina, N. S. AU - Erb, T. J. PY - 2016 DA - 2016// TI - A chemo-enzymatic road map to the synthesis of CoA esters JO - Molecules VL - 21 ID - Peter2016 ER - TY - JOUR AU - Zimmermann, M. AU - Thormann, V. AU - Sauer, U. AU - Zamboni, N. PY - 2013 DA - 2013// TI - Nontargeted profiling of coenzyme A thioesters in biological samples by tandem mass spectrometry JO - Anal Chem VL - 85 ID - Zimmermann2013 ER - TY - JOUR AU - Kanehisa, M. AU - Goto, S. PY - 2000 DA - 2000// TI - KEGG: kyoto encyclopedia of genes and genomes JO - Nucleic Acids Res VL - 28 ID - Kanehisa2000 ER - TY - JOUR AU - Kanehisa, M. AU - Sato, Y. AU - Furumichi, M. AU - Morishima, K. AU - Tanabe, M. PY - 2019 DA - 2019// TI - New approach for understanding genome variations in KEGG JO - Nucleic Acids Res VL - 47 ID - Kanehisa2019 ER - TY - JOUR AU - Rebets, Y. AU - Brotz, E. AU - Manderscheid, N. AU - Tokovenko, B. AU - Myronovskyi, M. AU - Metz, P. AU - Petzke, L. AU - Luzhetskyy, A. PY - 2015 DA - 2015// TI - Insights into the pamamycin biosynthesis JO - Angew Chem VL - 54 ID - Rebets2015 ER - TY - JOUR AU - Gemperlein, K. AU - Dietrich, D. AU - Kohlstedt, M. AU - Zipf, G. AU - Bernauer, H. S. AU - Wittmann, C. AU - Wenzel, S. C. AU - Müller, R. PY - 2019 DA - 2019// TI - Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases JO - Nat Commun VL - 10 ID - Gemperlein2019 ER - TY - JOUR AU - Poblete-Castro, I. AU - Binger, D. AU - Rodrigues, A. AU - Becker, J. AU - Martins Dos Santos, V. A. AU - Wittmann, C. PY - 2013 DA - 2013// TI - In-silico-driven metabolic engineering of Pseudomonas putida for enhanced production of poly-hydroxyalkanoates JO - Metab Eng VL - 15 ID - Poblete-Castro2013 ER - TY - JOUR AU - Kang, A. AU - Lee, T. S. PY - 2015 DA - 2015// TI - Converting sugars to biofuels: ethanol and beyond JO - Bioengineering VL - 2 ID - Kang2015 ER - TY - JOUR AU - Kind, S. AU - Becker, J. AU - Wittmann, C. PY - 2013 DA - 2013// TI - Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway–metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum JO - Metab Eng VL - 15 ID - Kind2013 ER - TY - JOUR AU - Schada von Borzyskowski, L. AU - Sonntag, F. AU - Poschel, L. AU - Vorholt, J. A. AU - Schrader, J. AU - Erb, T. J. AU - Buchhaupt, M. PY - 2018 DA - 2018// TI - Replacing the ethylmalonyl-CoA pathway with the glyoxylate shunt provides metabolic flexibility in the central carbon metabolism of Methylobacterium extorquens AM1 JO - ACS Synth Biol VL - 7 ID - Schada von Borzyskowski2018 ER - TY - JOUR AU - Huang, Y. Y. AU - Jian, X. X. AU - Lv, Y. B. AU - Nian, K. Q. AU - Gao, Q. AU - Chen, J. AU - Wei, L. J. AU - Hua, Q. PY - 2018 DA - 2018// TI - Enhanced squalene biosynthesis in Yarrowia lipolytica based on metabolically engineered acetyl-CoA metabolism JO - J Biotechnol VL - 281 ID - Huang2018 ER - TY - JOUR AU - Lu, C. AU - Zhang, X. AU - Jiang, M. AU - Bai, L. PY - 2016 DA - 2016// TI - Enhanced salinomycin production by adjusting the supply of polyketide extender units in Streptomyces albus JO - Metab Eng VL - 35 ID - Lu2016 ER - TY - JOUR AU - Martinez-Garcia, E. AU - Nikel, P. I. AU - Aparicio, T. AU - Lorenzo, V. PY - 2014 DA - 2014// TI - Pseudomonas 2.0: genetic upgrading of P. putida KT2440 as an enhanced host for heterologous gene expression JO - Microbial cell factories VL - 13 ID - Martinez-Garcia2014 ER - TY - JOUR AU - Botella, L. AU - Lindley, N. D. AU - Eggeling, L. PY - 2009 DA - 2009// TI - Formation and metabolism of methylmalonyl coenzyme A in Corynebacterium glutamicum JO - J Bacteriol VL - 191 ID - Botella2009 ER - TY - JOUR AU - Peyraud, R. AU - Kiefer, P. AU - Christen, P. AU - Massou, S. AU - Portais, J. C. AU - Vorholt, J. A. PY - 2009 DA - 2009// TI - Demonstration of the ethylmalonyl-CoA pathway by using 13C metabolomics JO - Proc Natl Acad Sci USA VL - 106 ID - Peyraud2009 ER - TY - JOUR AU - Seifar, R. M. AU - Ras, C. AU - Deshmukh, A. T. AU - Bekers, K. M. AU - Suarez-Mendez, C. A. AU - Cruz, A. L. AU - Gulik, W. M. AU - Heijnen, J. J. PY - 2013 DA - 2013// TI - Quantitative analysis of intracellular coenzymes in Saccharomyces cerevisiae using ion pair reversed phase ultra high performance liquid chromatography tandem mass spectrometry JO - J Chromatogr A VL - 1311 ID - Seifar2013 ER - TY - JOUR AU - Park, J. W. AU - Jung, W. S. AU - Park, S. R. AU - Park, B. C. AU - Yoon, Y. J. PY - 2007 DA - 2007// TI - Analysis of intracellular short organic acid-coenzyme A esters from actinomycetes using liquid chromatography-electrospray ionization-mass spectrometry JO - Journal of mass spectrometry: JMS VL - 42 ID - Park2007 ER - TY - JOUR AU - Rost, L. M. AU - Brekke Thorfinnsdottir, L. AU - Kumar, K. AU - Fuchino, K. AU - Eide Langorgen, I. AU - Bartosova, Z. AU - Kristiansen, K. A. AU - Bruheim, P. PY - 2020 DA - 2020// TI - Absolute quantification of the central carbon metabolome in eight commonly applied prokaryotic and eukaryotic model systems JO - Metabolites VL - 10 ID - Rost2020 ER - TY - JOUR AU - Bolten, C. J. AU - Kiefer, P. AU - Letisse, F. AU - Portais, J. C. AU - Wittmann, C. PY - 2007 DA - 2007// TI - Sampling for metabolome analysis of microorganisms JO - Anal Chem VL - 79 ID - Bolten2007 ER - TY - JOUR AU - Wittmann, C. AU - Krömer, J. O. AU - Kiefer, P. AU - Binz, T. AU - Heinzle, E. PY - 2004 DA - 2004// TI - Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria JO - Anal Biochem VL - 327 ID - Wittmann2004 ER - TY - JOUR AU - Wittmann, C. PY - 2007 DA - 2007// TI - Fluxome analysis using GC-MS JO - Microb Cell Fact VL - 6 ID - Wittmann2007 ER - TY - JOUR AU - Weber, R. J. M. AU - Lawson, T. N. AU - Salek, R. M. AU - Ebbels, T. M. D. AU - Glen, R. C. AU - Goodacre, R. AU - Griffin, J. L. AU - Haug, K. AU - Koulman, A. AU - Moreno, P. PY - 2017 DA - 2017// TI - Computational tools and workflows in metabolomics: an international survey highlights the opportunity for harmonisation through Galaxy JO - Metabolomics VL - 13 ID - Weber2017 ER - TY - JOUR AU - Park, Y. K. AU - Ledesma-Amaro, R. AU - Nicaud, J. M. PY - 2019 DA - 2019// TI - De novo biosynthesis of odd-chain fatty acids in Yarrowia lipolytica enabled by modular pathway engineering JO - Front Bioeng Biotechnol VL - 7 ID - Park2019 ER - TY - JOUR AU - Kohlstedt, M. AU - Wittmann, C. PY - 2019 DA - 2019// TI - GC-MS-based (13)C metabolic flux analysis resolves the parallel and cyclic glucose metabolism of Pseudomonas putida KT2440 and Pseudomonas aeruginosa PAO1 JO - Metab Eng VL - 54 ID - Kohlstedt2019 ER - TY - JOUR AU - Becker, J. AU - Klopprogge, C. AU - Schroder, H. AU - Wittmann, C. PY - 2009 DA - 2009// TI - Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum JO - Appl Environ Microbiol VL - 75 ID - Becker2009 ER - TY - JOUR AU - Sonntag, K. AU - Eggeling, L. AU - Graaf, A. A. AU - Sahm, H. PY - 1993 DA - 1993// TI - Flux partitioning in the split pathway of lysine synthesis in Corynebacterium glutamicum. Quantification by 13C- and 1H-NMR spectroscopy JO - Eur J Biochem VL - 213 ID - Sonntag1993 ER - TY - JOUR AU - Becker, J. AU - Zelder, O. AU - Hafner, S. AU - Schröder, H. AU - Wittmann, C. PY - 2011 DA - 2011// TI - From zero to hero–design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production JO - Metab Eng VL - 13 ID - Becker2011 ER - TY - JOUR AU - Zhang, Y. AU - Shang, X. AU - Wang, B. AU - Hu, Q. AU - Liu, S. AU - Wen, T. PY - 2019 DA - 2019// TI - Reconstruction of tricarboxylic acid cycle in Corynebacterium glutamicum with a genome-scale metabolic network model for trans-4-hydroxyproline production JO - Biotechnol Bioeng VL - 116 ID - Zhang2019 ER - TY - JOUR AU - Milke, L. AU - Kallscheuer, N. AU - Kappelmann, J. AU - Marienhagen, J. PY - 2019 DA - 2019// TI - Tailoring Corynebacterium glutamicum towards increased malonyl-CoA availability for efficient synthesis of the plant pentaketide noreugenin JO - Microb Cell Fact VL - 18 ID - Milke2019 ER - TY - JOUR AU - Kallscheuer, N. AU - Kage, H. AU - Milke, L. AU - Nett, M. AU - Marienhagen, J. PY - 2019 DA - 2019// TI - Microbial synthesis of the type I polyketide 6-methylsalicylate with Corynebacterium glutamicum JO - Appl Microbiol Biotechnol VL - 103 ID - Kallscheuer2019 ER - TY - JOUR AU - Chang, Z. AU - Dai, W. AU - Mao, Y. AU - Cui, Z. AU - Wang, Z. AU - Chen, T. PY - 2020 DA - 2020// TI - Engineering Corynebacterium glutamicum for the efficient production of 3-hydroxypropionic acid from a mixture of glucose and acetate via the malonyl-CoA pathway JO - Catalysts VL - 10 ID - Chang2020 ER - TY - JOUR AU - Zhang, Y. Q. AU - Brock, M. AU - Keller, N. P. PY - 2004 DA - 2004// TI - Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans JO - Genetics VL - 168 ID - Zhang2004 ER - TY - JOUR AU - Dolan, S. K. AU - Wijaya, A. AU - Geddis, S. M. AU - Spring, D. R. AU - Silva-Rocha, R. AU - Welch, M. PY - 2018 DA - 2018// TI - Loving the poison: the methylcitrate cycle and bacterial pathogenesis JO - Microbiology VL - 164 ID - Dolan2018 ER - TY - JOUR AU - Xu, Z. AU - Liu, Y. AU - Ye, B. C. PY - 2018 DA - 2018// TI - PccD regulates branched-chain amino acid degradation and exerts a negative effect on erythromycin production in Saccharopolyspora erythraea JO - Appl Environ Microbiol VL - 84 ID - Xu2018 ER - TY - JOUR AU - Helfrich, E. J. AU - Piel, J. PY - 2016 DA - 2016// TI - Biosynthesis of polyketides by trans-AT polyketide synthases JO - Nat Prod Rep VL - 33 ID - Helfrich2016 ER - TY - JOUR AU - Dayem, L. C. AU - Carney, J. R. AU - Santi, D. V. AU - Pfeifer, B. A. AU - Khosla, C. AU - Kealey, J. T. PY - 2002 DA - 2002// TI - Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli JO - Biochemistry VL - 41 ID - Dayem2002 ER - TY - JOUR AU - Gross, F. AU - Ring, M. W. AU - Perlova, O. AU - Fu, J. AU - Schneider, S. AU - Gerth, K. AU - Kuhlmann, S. AU - Stewart, A. F. AU - Zhang, Y. AU - Müller, R. PY - 2006 DA - 2006// TI - Metabolic engineering of Pseudomonas putida for methylmalonyl-CoA biosynthesis to enable complex heterologous secondary metabolite formation JO - Chem Biol VL - 13 ID - Gross2006 ER - TY - JOUR AU - Wang, J. AU - Wang, C. AU - Song, K. AU - Wen, J. PY - 2017 DA - 2017// TI - Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus JO - Microb Cell Fact VL - 16 ID - Wang2017 ER - TY - STD TI - Kuhl M, Gläser L, Rebets Y, Rückert C, Sarkar N, Hartsch T, Kalinowksi J, Luzhetskyy A, Wittmann C: Microparticles globally reprogram the metabolism of Streptomyces albus towards accelerated morphogenesis, streamlined carbon core metabolism and enhanced production of the antituberculosis polyketide pamamycin. Biotechnol Bioeng 2020, submitted. ID - ref45 ER - TY - JOUR AU - Natsume, M. AU - Tazawa, J. AU - Yagi, K. AU - Abe, H. AU - Kondo, S. AU - Marumo, S. PY - 1995 DA - 1995// TI - Structure-activity relationship of pamamycins: effects of alkyl substituents JO - J Antibiotics VL - 48 ID - Natsume1995 ER - TY - JOUR AU - Kozone, I. AU - Chikamoto, N. AU - Abe, H. AU - Natsume, M. PY - 1999 DA - 1999// TI - De-N-methylpamamycin-593A and B, new pamamycin derivatives isolated from Streptomyces alboniger JO - J Antibiotics VL - 52 ID - Kozone1999 ER - TY - JOUR AU - Natsume, M. AU - Yasui, K. AU - Kondo, S. AU - Marumo, S. PY - 1991 DA - 1991// TI - The structure of four new pamamycin homologues isolated from Streptomyces alboniger JO - Tetrahedron Lett VL - 32 ID - Natsume1991 ER - TY - BOOK AU - Kieser, T. AU - Bibb, M. AU - Buttner, M. AU - Chater, K. AU - Hopwood, D. PY - 2000 DA - 2000// TI - Practical streptomyces genetics John Innes Foundation PB - Norwich CY - United Kingdom ID - Kieser2000 ER - TY - JOUR AU - Krömer, J. O. AU - Fritz, M. AU - Heinzle, E. AU - Wittmann, C. PY - 2005 DA - 2005// TI - In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum JO - Anal Biochem VL - 340 ID - Krömer2005 ER - TY - JOUR AU - Schneider, K. AU - Peyraud, R. AU - Kiefer, P. AU - Christen, P. AU - Delmotte, N. AU - Massou, S. AU - Portais, J. C. AU - Vorholt, J. A. PY - 2012 DA - 2012// TI - The ethylmalonyl-CoA pathway is used in place of the glyoxylate cycle by Methylobacterium extorquens AM1 during growth on acetate JO - J Biol Chem VL - 287 ID - Schneider2012 ER - TY - JOUR AU - Mashego, M. R. AU - Wu, L. AU - Dam, J. C. AU - Ras, C. AU - Vinke, J. L. AU - Winden, W. A. AU - Gulik, W. M. AU - Heijnen, J. J. PY - 2004 DA - 2004// TI - MIRACLE: mass isotopomer ratio analysis of U-13C-labeled extracts. A new method for accurate quantification of changes in concentrations of intracellular metabolites JO - Biotechnol Bioeng VL - 85 ID - Mashego2004 ER - TY - JOUR AU - Metsalu, T. AU - Vilo, J. PY - 2015 DA - 2015// TI - ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap JO - Nucleic Acids Res VL - 43 ID - Metsalu2015 ER -