Fig. 1From: Design and development of a chimeric vaccine candidate against zoonotic hepatitis E and foot-and-mouth diseaseProtrusion index of key-epitope sites of HEV and FMDV antigens within the HEV-FMDV chimeric proteins as calculated by the Ellipro web server. This figure shows the protrusion index of the key-epitope sites: a in the HEV antigens alone and when they are attached to the N-terminal of the FMDV Seq 8 antigen; b in the HEV antigens alone and when they are attached to the C-terminal of the FMDV Seq 8 antigen; and c in the FMDV Seq 8 antigen when it is attached to the N-terminal or C-terminal of the different HEV antigens. Next, the total areas under the curves of the protrusion indexes were calculated for each protein using GraphPadPrizm5 Software (d–f) and are shown in d for the HEV antigens alone and when they are attached to either the N- or C-terminal of the FMDV Seq 8 antigen; and in e for the FMDV Seq 8 antigen when it is attached to either the N- or C-terminal of the HEV antigens. The normalized AUCs of the protrusion indexes of the key epitopes for both HEV and FMDV fragments in the different chimeric proteins are summarized in fBack to article page