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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Design and development of a chimeric vaccine candidate against zoonotic hepatitis E and foot-and-mouth disease

Fig. 1

Protrusion index of key-epitope sites of HEV and FMDV antigens within the HEV-FMDV chimeric proteins as calculated by the Ellipro web server. This figure shows the protrusion index of the key-epitope sites: a in the HEV antigens alone and when they are attached to the N-terminal of the FMDV Seq 8 antigen; b in the HEV antigens alone and when they are attached to the C-terminal of the FMDV Seq 8 antigen; and c in the FMDV Seq 8 antigen when it is attached to the N-terminal or C-terminal of the different HEV antigens. Next, the total areas under the curves of the protrusion indexes were calculated for each protein using GraphPadPrizm5 Software (d–f) and are shown in d for the HEV antigens alone and when they are attached to either the N- or C-terminal of the FMDV Seq 8 antigen; and in e for the FMDV Seq 8 antigen when it is attached to either the N- or C-terminal of the HEV antigens. The normalized AUCs of the protrusion indexes of the key epitopes for both HEV and FMDV fragments in the different chimeric proteins are summarized in f

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