Fig. 6From: Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategiesFermentation of the optimized strain JPT-M, which was constructed by combining multiple strategies. The strains for fermentation in the same batch also include: the control strain FH215-HBA, containing exogenous precursor module strain JPT25, hemE knockdown strain JPT-E1000, cysG knockdown strain JPT-G2000. Error bars indicate standard deviations from three biological replicatesBack to article page