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Fig. 5 | Microbial Cell Factories

Fig. 5

From: Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies

Fig. 5

Effect of modified metabolic branch on HBA biosynthesis. a, b Effect of weakening the heme pathway on HBA biosynthesis. The intracellular heme concentration (a), HBA titer and growth status (b) of each strain from 12 to 24 h after induction. c Effect of weakening the siroheme pathway on HBA biosynthesis. The HBA titer and growth status of each strain from 12 h to 24 h after induction. The hemE knockdown strains: JPT-E100, JPT-E500, JPT-E1000, JPT-E2000. The cysG knockdown strains: JPT-G100, JPT-G500, JPT-G2000. The cysG knockout strain: JPT-DEcysG. Control: JPT25D2B6. Error bars indicate standard deviations from three biological replicates

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Microbial Cell Factories

ISSN: 1475-2859

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