Microbial Cell Factories

Table 4 Comparison of the production of acetoin via microbial fermentation process in the literature and in this study

From: Engineering central pathways for industrial-level (3R)-acetoin biosynthesis in Corynebacterium glutamicum

Strains/enzymes	Substrate	Titer (g/L)	Enantiomer	Yield (g/g)	Productivity (g/L/h)	Refs.
Production of optically pure acetoin
C. glutamicum CGS11	Glucose	102.45	(3R)-	0.419	1.86	This study
C. glutamicum CGR7	Glucose	96.20	(3R)-	0.360	1.30	[9]
Bacillus subtilis CGMCC 13141	Glucose	83.70	(3R)-	0.448	1.02	[25]
Klebsiella pneumoniae	Glucose	62.30	(3R)-	0.140	1.09	[20]
E. coli (pAC-NOX)	Glucose	60.30	(3R)-	0.422	1.55	[58]
Bacillus subtilis DL01	Sugarcane molasses	58.20	(3R)-	0.291	0.77	[59]
Lactococcus lactis CS4701m	Glucose	5.80	(3S)-	0.347	0.19	[23]
Production of racemic acetoin (or optical purity not stated)
S. cerevisiae JHY617-SDN	Glucose	100.10	Ng	0.440	1.82	[16]
Gluconobacter oxydans DSM 2003	2,3-Butanediol	89.20	Ng	0.891	1.24	[60]
B. subtilis HS019	Glucose	82.50	Ng	0.460	1.33	[53]
Bacillus licheniformis WX-02ΔbudCΔacoR	Glucose	78.80	Ng	0.310	0.58	[7]
S. marcescens H32-nox	Sucrose	75.20	Ng	0.360	1.88	[61]
Enterobacter aerogenes EJW-03	Glucose	71.70	Ng	0.320	2.87	[62]
B. amyloliquefaciens E-11	Glucose	71.50	Ng	0.413	1.63	[52]
B. licheniformis MW3 (△budC△gdh)	Glucose	64.20	Ng	0.412	2.38	[63]
B. subtilis ZB02	Glucose, xylose, and arabinose	62.20	Ng	0.288	0.86	[64]
S. marcescens H32	Sucrose	60.50	Ng	Ng	1.44	[65]
B. subtilis F126-2	Glycerol	60.48	Ng	Ng	1.26	[66]
Lactococcus lactis CML B4	Glucose	59.00	Ng	0.360	2.11	[67]
Paenibacillus polymyxa CJX518	Glucose	57.20	Ng	0.400	0.30	[68]
B. subtilis TH-49	Glucose	56.90	Ng	Ng	0.89	[69]
B. subtilis BMN	Glucose	56.70	Ng	0.378	0.68	[70]
P. polymyxa CS107	Glucose	55.30	Ng	0.370	1.32	[71]
B. subtilis JNA-UD-6	Glucose	53.90	Ng	0.359	0.37	[72]
Enterobacter cloacae SDM 45	Glucose	55.20	Ng	0.373	2.69	[73]
Enterobacter cloacae SDM 45	Lignocellulosic hydrolysate	45.60	Ng	NG	1.52	[73]
B. amyloliquefaciens FMME044	Glucose	51.20	Ng	0.430	1.42	[74]
Bacillus sp. H15-1.	Degermed maize flour hydrolysate	50.80	Ng	0.285	NG	[75]
C. glutamicum CGT2	Glucose	40.51	Ng	0.240	0.51	[76]

Ng indicates that the related information is Not Given

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