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Table 1 Significance metabolites in fecal samples of HFD, HS and HE

From: Engineered butyrate-producing bacteria prevents high fat diet-induced obesity in mice

Identification Pathway Content level Significance
l-Methionine Methionine metabolism HFD > HE 9.14 ± 0.151 vs 8.84 ± 0.236*
Spermine Glutathione metabolism HFD > HE 7.90 ± 0.254 vs 7.51 ± 0.228**
Pyroglutamic acid Glutathione metabolism HFD > HE 7.61 ± 0.164 vs 7.37 ± 0.200**
N8-Acetylspermidine   HFD > HE 7.39 ± 0.219 vs 7.18 ± 0.272*
O-Succinylhomoserine Methionine metabolism HFD > HE 6.95 ± 0.168 vs 6.32 ± 0.4928*
l-Dopa Tyrosine metabolism HFD < HE 6.73 ± 0.066 vs 6.99 ± 0.222**
Homogentisic acid Tyrosine metabolism HFD < HE 5.00 ± 0.350 vs 5.94 ± 0.320***
l-Homophenylalanine Phenylalanine, tyrosine and tryptophan biosynthesis HFD > HE
HFD > HS
7.55 ± 0.108 vs 7.33 ± 0.122**
7.55 ± 0.108 vs 7.29 ± 0.075##
l-Phenylalanine Phenylalanine metabolism HFD > HE 9.81 ± 0.108 vs 9.59 ± 0.251*
Deoxycholic acid Secondary bile acid biosynthesis HFD > HE 6.87 ± 0.117 vs 6.72 ± 0.118*
Pentadecanoic acid   HFD < HE 7.48 ± 0.124 vs 7.81 ± 0.102***
Guanine Purine metabolism HFD > HE 8.27 ± 0.216 vs 7.97 ± 0.469*
Adenine Purine metabolism HFD > HE 8.97 ± 0.110 vs 8.88 ± 0.114**
Deoxyguanosine Purine metabolism HFD > HE 7.86 ± 0.264 vs 7.64 ± 0.416*
Dihydrouracil Pyrimidine metabolism HFD > HE 8.79 ± 0.111 vs 8.59 ± 0.263**
5-Methyltetrahydrofolate One carbon pool by folate, carbon fixation pathways in prokaryotes HFD > HE 5.78 ± 0.075 vs 5.38 ± 0.108**
  1. *HFD vs HE; #HFD vs HS. */#p value < 0.05, **/##p < 0.01 and ***/###p < 001