Engineered butyrate-producing bacteria prevents high fat diet-induced obesity in mice

Table 1 Significance metabolites in fecal samples of HFD, HS and HE

Identification	Pathway	Content level	Significance
l-Methionine	Methionine metabolism	HFD > HE	9.14 ± 0.151 vs 8.84 ± 0.236*
Spermine	Glutathione metabolism	HFD > HE	7.90 ± 0.254 vs 7.51 ± 0.228**
Pyroglutamic acid	Glutathione metabolism	HFD > HE	7.61 ± 0.164 vs 7.37 ± 0.200**
N8-Acetylspermidine		HFD > HE	7.39 ± 0.219 vs 7.18 ± 0.272*
O-Succinylhomoserine	Methionine metabolism	HFD > HE	6.95 ± 0.168 vs 6.32 ± 0.4928*
l-Dopa	Tyrosine metabolism	HFD < HE	6.73 ± 0.066 vs 6.99 ± 0.222**
Homogentisic acid	Tyrosine metabolism	HFD < HE	5.00 ± 0.350 vs 5.94 ± 0.320***
l-Homophenylalanine	Phenylalanine, tyrosine and tryptophan biosynthesis	HFD > HE HFD > HS	7.55 ± 0.108 vs 7.33 ± 0.122** 7.55 ± 0.108 vs 7.29 ± 0.075^##
l-Phenylalanine	Phenylalanine metabolism	HFD > HE	9.81 ± 0.108 vs 9.59 ± 0.251*
Deoxycholic acid	Secondary bile acid biosynthesis	HFD > HE	6.87 ± 0.117 vs 6.72 ± 0.118*
Pentadecanoic acid		HFD < HE	7.48 ± 0.124 vs 7.81 ± 0.102***
Guanine	Purine metabolism	HFD > HE	8.27 ± 0.216 vs 7.97 ± 0.469*
Adenine	Purine metabolism	HFD > HE	8.97 ± 0.110 vs 8.88 ± 0.114**
Deoxyguanosine	Purine metabolism	HFD > HE	7.86 ± 0.264 vs 7.64 ± 0.416*
Dihydrouracil	Pyrimidine metabolism	HFD > HE	8.79 ± 0.111 vs 8.59 ± 0.263**
5-Methyltetrahydrofolate	One carbon pool by folate, carbon fixation pathways in prokaryotes	HFD > HE	5.78 ± 0.075 vs 5.38 ± 0.108**

^*HFD vs HE; ^#HFD vs HS. */^#p value < 0.05, **/^##p < 0.01 and ***/^###p < 001

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