Repeated fed-batch strategy and metabolomic analysis to achieve high docosahexaenoic acid productivity in Crypthecodinium cohnii

Table 4 Comparison of DHA productivity using C. cohnii by different culture strategies

Culture strategy	Crypthecodinium cohnii	Carbon source	Fermentation time (h)	DHA productivity (mg/L/h)	References
Fed-batch	CCMP 316	Glucose	135	9.78	[48]
Batch	ATCC 30772	Glucose	91	17.58	[24]
Fed-batch	CCMP 316	Carob pulp	100	19.00	[49]
Fed-batch	ATCC 30556	Date syrup	240	23.54	[7]
Fed-batch	ATCC 30772	Acetic acid	400	47.50	[8]
Fed-batch	ATCC 30772	Ethanol	220	53.18	[9]
Fed-batch	M-1-2	Glucose	168	57.08	[3]
Repeated fed-batch cycle 1	M-1-2	Glucose	120	51.54	This study
Repeated fed-batch cycle 2	M-1-2	Glucose	120	50.43	This study
Repeated fed-batch cycle 3	M-1-2	Glucose	120	50.94	This study
Repeated fed-batch cycle 4	M-1-2	Glucose	120	48.97	This study

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