Repeated fed-batch strategy and metabolomic analysis to achieve high docosahexaenoic acid productivity in Crypthecodinium cohnii

Table 1 Comparison of DHA production at the end of each cycle using different glucose concentrations

Glucose Conc. (g/L)	Cycle	Fermentation time (h)	Dry cell weight (g/L)	DHA (g/L)	DHA productivity^a (mg/L/h)
5.00–15.00	Cycle 1	120	30.38 ± 0.12	3.41 ± 0.03	28.44 ± 0.24
5.00–15.00	Cycle 2	120	26.72 ± 0.49	2.99 ± 0.01	24.93 ± 0.10
15.00–27.00	Cycle 1	120	45.17 ± 0.71	5.42 ± 0.02	45.14 ± 0.15
15.00–27.00	Cycle 2	120	43.57 ± 1.37	5.14 ± 0.04	42.84 ± 0.30
27.00–45.00	Cycle 1	120	34.69 ± 0.35	3.90 ± 0.01	32.54 ± 0.12
27.00–45.00	Cycle 2	120	40.62 ± 0.63	4.25 ± 0.03	35.40 ± 0.25

^aDHA productivity of each cycle (the DHA produced at the end of each cycle/the time of each cycle operation)

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