Table 2 Conversion yields for different substrates of hFMO3 using whole-cell catalysis at 37 °C within 24 h
From: Production of drug metabolites by human FMO3 in Escherichia coli
Substrate | N-oxide product (mg/L) | Conversion (%) |
|---|---|---|
Clomiphene | 392.4 ± 1.7 | 93.0 ± 0.4 |
Dasatinib | 499.0 ± 3.5 | 99.0 ± 0.7 |
GSK5182 | 208.8 ± 1.5 | 98.4 ± 0.7 |
Tozasertib | 201.8 ± 2.9 | 42.0 ± 0.6 |