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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli

Fig. 1

Biosynthesis scheme for producing two acridone derivatives in Escherichia coli. Dotted arrows represent the metabolic pathways in E. coli. Bold arrows indicate the pathway engineered for the synthesis of the two acridones (dihydroxyacridone (DHA) and N-methylacridone (NMA)). Introduced genes are as follows: ACS, acridone synthase from Ruta graveolens; badA, benzoate CoA ligase from R. palustris; pqsA, anthranilate coenzyme A ligase from P. aeruginosa; NMT, N-methyltransferase from Ruta graveolens; acs, acetyl-CoA synthase, PDH, pyruvate dehydrogenase complex, ackA & pta, acetate kinase A & phosphate acetyltransferase from E. coli; and acc, acetyl-coenzyme A carboxylase from Photorhabdus luminescens

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Microbial Cell Factories

ISSN: 1475-2859

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