Fig. 1

T2D contributes to therapy resistance in PDAC. Schematic diagram of the experimental setup. Arrows indicate Streptozotocin (STZ) administration and fecal matter collection. C1, C2, C3, C4 refer to control groups that do not receive STZ or high fat diet D1, D2, D3, D4 refer to animals receiving STZ and put on high fat diet. C4 and D4 groups were further split into C4′ and D4′ to indicate groups that received Gem/Pac therapy (a). Blood glucose (b) and blood cholesterol (c) was measured at the end of 1 month to validate hyperglycemia and T2D onset in animals. After tumor implantation and 1 month of Gem/Pac, T2D group animals did not show any significant change in tumor volume (e) or weight (f), while the control tumors responded to the standard of care. *Indicates p value = 0.05