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Table 1 Biological activities of notonesomycins A and B

From: Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Target organism or cell line (ATCC® number)Activitya (μM)
AB
Candida albicans (ATCC® 90028™)6.21.3
Aspergillus fumigatus (ATCC® 46645™)16.84.1
A549 Human lung carcinoma cells (ATCC® CCL-185™)0.240.70
PANC-1 Human pancreas carcinoma cells (ATCC® CRL-1469™)0.250.74
HepG2 Human liver carcinoma cells (ATCC® HB-8065™)0.260.72
Staphylococcus aureus Rosenbach (ATCC® 25923™)19.318.5
Escherichia coli (ATCC® 25922™)> 60> 60
  1. aIC90 for bacterial assays and IC50 for fungi and mammalian cell assay