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Table 1 Biological activities of notonesomycins A and B

From: Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Target organism or cell line (ATCC® number) Activitya (μM)
A B
Candida albicans (ATCC® 90028™) 6.2 1.3
Aspergillus fumigatus (ATCC® 46645™) 16.8 4.1
A549 Human lung carcinoma cells (ATCC® CCL-185™) 0.24 0.70
PANC-1 Human pancreas carcinoma cells (ATCC® CRL-1469™) 0.25 0.74
HepG2 Human liver carcinoma cells (ATCC® HB-8065™) 0.26 0.72
Staphylococcus aureus Rosenbach (ATCC® 25923™) 19.3 18.5
Escherichia coli (ATCC® 25922™) > 60 > 60
  1. aIC90 for bacterial assays and IC50 for fungi and mammalian cell assay