Table 1 Biological activities of notonesomycins A and B
From: Identification and engineering of 32 membered antifungal macrolactone notonesomycins
Target organism or cell line (ATCC® number) | Activitya (μM) | |
|---|---|---|
A | B | |
Candida albicans (ATCC® 90028™) | 6.2 | 1.3 |
Aspergillus fumigatus (ATCC® 46645™) | 16.8 | 4.1 |
A549 Human lung carcinoma cells (ATCC® CCL-185™) | 0.24 | 0.70 |
PANC-1 Human pancreas carcinoma cells (ATCC® CRL-1469™) | 0.25 | 0.74 |
HepG2 Human liver carcinoma cells (ATCC® HB-8065™) | 0.26 | 0.72 |
Staphylococcus aureus Rosenbach (ATCC® 25923™) | 19.3 | 18.5 |
Escherichia coli (ATCC® 25922™) | > 60 | > 60 |