Fig. 2

Schematic overview of the relevant pathways for flavin production. (Pathways) PP pathway, the pentose phosphate pathway; TCA, the tricarboxylic acid cycle; EMP, the Embden–Meyerhof pathway/glycolysis; ED, the Entner–Doudoroff pathway. (Metabolites) G6P, Glucose-6-phosphate; GAP, Glyceraldehyde 3-phosphate; 3GP, Glycerate 3-phosphate; PYR, Pyruvate; OAA, Oxaloacetate; 6-Pgdl, 6-Phospho-d-glucono-1,5-lactone; Gluconate-6P, 6-Phospho-d-gluconate; PRPP, Phosphoribosylpyrophosphate; Ru5P, Ribulose 5-phosphate; GTP, Guanosine 5′-triphosphate; Gly, Glycine; GTP, guanosine 5′-triphosphate; DHPB, L-3,4-Dihydroxybutan-2-one 4-phosphate; DARPP, 2,5-Diamino-6-(1-d-ribosylamino)pyrimidin-4(3H)-one 5′-phosphate; AFAPP, 2-Amino-5-formylamino-6-(5-phospho-d-ribosylamino)pyrimidin-4(3H)-one; DArPP, 2,5-Diamino-6-(1-d-ribitylamino)pyrimidin-4(3H)-one 5′-phosphate; ARPP, 5-Amino-6-(ribosylamino)-2,4-(1H,3H)-pyrimidinedione 5′-phosphate; ArPP, 5-Amino-2,6-dioxy-4-(5′-phospho-d-ribitylamino)pyrimidine; ArP, 5-Amino-6-(1-d-ribitylamino)uracil; DrL, 6,7-Dimethyl-8-(D-ribityl)lumazine; RF, Riboflavin; FMN, Flavin mononucleotide; FAD, Flavin adenine dinucleotide; (Enzymes that catalyze the Reactions) I, GTP cyclohydrolase II, (EC: 3.5.4.25); ①, GTP cyclohydrolase IIa, (EC: 3.5.4.29); ②, AFAPP deformylase (EC: 3.5.1.102); II & III, deaminase (EC: 3.5.4.26) & reductase (EC: 1.1.1.193); ③ & ④, reductase (EC: 1.1.1.302) & deaminase (EC: 5.4.99.28); IV, 5-amino-6-(5-phospho-d-ribitylamino)uracil phosphatase (EC: 3.1.3.104); V, DHPB synthase (EC: 4.1.99.12); VI, 6,7-dimethyl-8-ribityllumazine synthase (EC: 2.5.1.78); VII, RF synthase (EC: 2.5.1.9) VIII, RF kinase; IX, FMN adenylyltransferase/FAD synthetase