Fig. 6

Schematic view of the metabolic pathway associated with bleomycin synthesis in S. verticillus. The precursors for bleomycin production were represented by colored rectangular boxes. The dashed arrows indicated that there were multiple reaction steps in this line. EMP, Embden–Meyerhof–Parnas pathway; PP, Pentose Phosphate pathway; PEP, Phosphoenolpyruvate; PRPP, 5-Phosphoribosyl 1-Pyrophosphate; TCA, Tricarboxylic acid cycle; AKG, α-Ketoglutaric acid