Effect of the TetR family transcriptional regulator Sp1418 on the global metabolic network of Saccharopolyspora pogona

Table 1 Proteins identified from SDS-PAGE gel analysis

Protein bands	UniProtKB	Protein description	Gene	MW (KDa)	Possible function
a	A0A0X3SRR8	Polyketide synthase BusE, partial	busE	219.9	Polyketide biosynthesis of butenyl-spinosyn
b	A0A2N3XQH8	DNA-directed RNA polymerase subunit beta’	rpoC	144.76	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
c	A0A2N3Y983	Translation initiation factor IF-2	infB	105.31	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
d	A0A2N3Y379	Oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase	paaZ	72.19	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
e	A0A2N3XV92	Catalase	katE	55.25	Hydrogen peroxide catabolic process, response to oxidative stress
f	A0A2N3Y9R3	D-3-phosphoglycerate dehydrogenase	serA	54.93	This protein is involved in step 1 of the subpathway that synthesizes l-serine from 3-phospho-D-glycerate
g	A0A1H3I9Q3	Molecular chaperone GroEL	groEL	59.12	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
h	D9WS96	Coproporphyrinogen III oxidase		43.04	Catalytic activity, iron-sulfur cluster binding
i	A0A0K9XIH0	Heme oxygenase		27.06	Heme oxygenase (decyclizing) activity, metal ion binding

ISSN: 1475-2859