Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Table 2 Antibacterial activity of auroramycin and its analogs

Compound	MIC, μg/mL
	Staphylococcus aureus (MRSA)	Staphylococcus aureus (VI-MRSA)	Enterococcus faecalis (VRE)
	Clinical N216	Clinical Z172	ATCC 51299
1	4	8	2–4
3^a	4	4–8	4
4	8–16	64	8
5	4–8	16	8
6	> 128	> 128	> 128
10	32	> 128	16

Minimum inhibitory concentration (MIC) refers to lowest concentration of an agent that completely inhibits visible in vitro growth of the indicated microorganism after 20 h incubation at 35 °C
^aCompound 3 tested in this MIC was isolated at a 7:1 ratio with analog 5

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