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Table 1 Antifungal activity of auroramycin and its analogs

From: Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Compound

Fungi (MIC, µg/mL)

Yeast (MIC, µg/mL)

 

Candida glabrata

Cryptococcus neoformans

Candida tropicalis

Candida albicans —azoles resistant

Saccharomyces cerevisiae

Kodameae ohmeri

 

ATCC 36583

ATCC 24067

ATCC 200956

ATCC 200918

ATCC 9763

CDC AR-BANK#0396

1

2

2

1

2

4

> 128

3a

2

1

1–2

2

2–4

2–4

4

> 128

> 128

64

> 128

> 128

> 128

5

> 128

64

> 128

> 128

> 128

>128

6

> 128

32

> 128

> 128

> 128

> 128

10

2

1

2

2

2

> 128

  1. Minimum inhibitory concentration (MIC) refers to lowest concentration of an agent that completely inhibits visible growth in vitro of the microorganism after 2 days at 28 °C for Saccharomyces cerevisiae and Kodameae ohmeri, and at 36 °C for Candida glabrata, Cryptococcus neoformans, Candida tropicalis and Candida albicans
  2. aThe compound 3 tested in this MIC was isolated at a 7:1 ratio with analog 5. As analog 5 was inactive in the assays, the bioactivity observed for compound 3 is attributed to analog 3
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Microbial Cell Factories

ISSN: 1475-2859

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