Fig. 6
From: Biosynthetic engineering of the antifungal, anti-MRSA auroramycin
Structural activity map of auroramycin. Red shaded: removal resulted in drastic loss of both antifungal and antibacterial bioactivities; green shaded: removal resulted in retention of activity or slightly better antifungal activity, including new bioactivity against K. ohmeri; yellow shaded: minimal changes in antifungal activity but loss in potency in antibacterial activity; dashed blue circle: essential for antifungal activity; enhanced antibacterial potency; dotted red circle: due to the low production yields and purities, biological activity of these analogs were not functionally characterized