Fig. 1
From: High production of valencene in Saccharomyces cerevisiae through metabolic engineering
The schematic of engineered mevalonate (MVA) pathway and relevant downstream pathways in S. cerevisiae. The heterologous valencene synthetic pathway is highlighted in red. ERG10, acetyl-CoA C-acetyltransferase; ERG13, hydroxymethylglutaryl-CoA synthase; ERG12, mevalonate kinase; tHMG1, truncated 3-hydroxy-3-methylglutaryl-CoA reductase; ERG8, phosphomevalonate kinase; ERG19, diphosphomevalonate decarboxylase; IDI1, isopentenyl-diphosphate delta-isomerase; ERG20, farnesyl diphosphate synthase/dimethylallyltranstransferase; ERG9, squalene synthase; BTS1, geranylgeranyl diphosphate synthase; CnVS, valencene synthase from Callitropsis nootkatensis