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Table 2 Concentration of MEP intermediates compared to the Km values of the downstream enzymes

From: Investigation of the methylerythritol 4-phosphate pathway for microbial terpenoid production through metabolic control analysis

Enzyme Km (µM) Concentration in E. coli (µM)
Dxs 226 GAPa 10.3b
Dxr 99c; 115d; 720e DXP 16.8 ± 0.7
IspD 61f; 370g MEP 0.75 ± 0.04
IspE 150h ME-CDP 0.92 ± 0.02
IspG 311i; 560–700j MEcPP 12.2 ± 0.01
Idi ~ 9.5/14.3k IPP/DMAPP 1.3 ± 0.2
  1. a [41]; b [40]; c [42]; d [43]; e [44]; f [48]; g [47]; h [54]; i [49]; j [55]; k [36]