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Fig. 4 | Microbial Cell Factories

Fig. 4

From: Exploring novel herbicidin analogues by transcriptional regulator overexpression and MS/MS molecular networking

Fig. 4

Alignment of DNA binding domain in LuxR regulators and prediction of its consensus binding site. a Structure-based alignment of the DNA binding domain (DBD) of HcdR2 with its structurally homologous proteins in different strains. Identities are boxed in red. Similarities are boxed in yellow according to physicochemical properties. Secondary structural elements from the 3D structure of TraR (PDB 1L3L) are displayed on the top of the sequence blocks. GenBank accession numbers of these LuxR regulators are as follows: S. sp. L-9-10 (Her12, RYJ25228.1), S. scopuliridis RB72 (PVE09951.1), S. sp. NRRL F-5135 (WP_078854789.1), S. acidiscabies strain a10 (GAQ51936.1), S. sp. V2 (PWG13438.1), S. ipomoeae 91-03 (EKX64212.1), S. sp. NRRL S-31 (WP_079165723.1), S. mobaraensis NBRC 13819 (EMF01239.1), S. sp. CB02959 (PJN35945.1), S. albulus CCRC 11814 (EPY92754.1), S. caeruleatus NRRL B-24802 (KUN91385.1), S. corchorusii DSM 40340 (KUN18075.1). b The predicted HcdR2 consensus binding site identified by MEME Suite. Inverted arrows denote the dyad symmetry

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