Fig. 1
From: Alpha-Terpineol production from an engineered Saccharomyces cerevisiae cell factory
Schematic overview of α-Terpineol biosynthesis in S. cerevisiae. The green arrows are the endogenous pathway in S. cerevisiae, and the purple indicates heterogeneous genes. Blue represents protein mutation, and the gray dashed line represents supposed feedback inhibition. Genes marked in red are overexpressed, ERG9 in cyan is weakened, and thoes in orange are deleted. Glc, glucose; acetyl-CoA, acetyl coenzyme A; tHMG1, truncated HMG-CoA reductase gene; HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate; IDI1, isopentenyl-diphosphate delta-isomerase gene; ERG20*, farnesyl diphosphate synthetase mutant gene; ERG9, squalene synthetase gene; FPP, farnesyl diphosphate; FOH, farnesol; LPP1, phosphatidate phosphatase gene LPP1; DPP1, phosphatidate phosphatase gene DPP1; ERG1, squalene monooxygenase synthase gene; GPP, geranyl diphosphate; VvTS, α-Terpineol synthase from Vitis vinifera