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Fig. 5 | Microbial Cell Factories

Fig. 5

From: Modification of acetoacetyl-CoA reduction step in Ralstonia eutropha for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from structurally unrelated compounds

Fig. 5

Proposed pathway for P(3HB-co-3HHx) biosynthesis from glucose by R. eutropha NSDG-GG-HC/pBPP-ccrMeJAc-emd. PhaA and BktB, β-ketothiolases; PhaB1 and PhaB3, NADPH-acetoacetyl-CoA reductases; Had, NAD-(S)-3HB-CoA dehydrogenase; Crt2, crotonase; PhaCNSDG, N149S/D171G mutant of PHA synthase from A. caviae; PhaJAc, short-chain-length-(R)-enoyl-CoA hydratase from A. caviae; CcrMe, crotonyl-CoA carboxylase/reductase from Methylorubrum extorquens; EmdMm, ethylmalonyl-CoA decarboxylase from Mus musculus

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