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Table 4 Comparison of titer and yield of AC and 2,3-BD produced by different strains through bioconversion in recent years

From: Synthetic engineering of Corynebacterium crenatum to selectively produce acetoin or 2,3-butanediol by one step bioconversion method

Strains Bioconversion method Substrates Products Titer (g L−1) Yield (mol mol−1) References
E. coli Fed batch DA AC 39.4 0.83 [36]
E. coli BL21 (DE3) Batch meso-2,3-BD (3R)-AC 86.7 0.94 [37]
E. coli BL21 (DE3) Batch meso-2,3-BD (3S)-AC 36.7 0.88 [21]
E. coli BL21 (DE3) Batch (2R,3R)-2,3-BD (3R)-AC 41.8 0.98 [21]
B. subtilis 168 Fed batch 2,3-BD AC 91.8 0.78 [22]
E. coli Batch meso-2,3-BD (3S)-AC 72.38 0.92 [38]
E. coli Batch meso-2,3-BD (2S,3S)-2,3-BD 38.41 0.96 [38]
E. coli BL21 (DE3) Fed batch DA (2S,3S)-2,3-BD 31.7 0.86 [39]
B. subtilis 168 Repeated batches AC + formate 2,3-BD 115.4 0.96 [40]
B. subtilis 168 Batch AC + glucose 2,3-BD 63.7 0.96 [40]
K. pneumoniae and B. subtilis 168 Two-step sequencing batch Glucose (3S)-AC 56.7 0.85 [41]
C. crenatumΔbutAΔldh SD Repeated batches Glucose AC 76.9 0.67 This study
C. crenatumΔldh SDA Repeated batches Glucose 2,3-BD 88.8 0.80 This study