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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Exploring the xylose paradox in Saccharomyces cerevisiae through in vivo sugar signalomics of targeted deletants

Fig. 1

Schematic representation of the signalling pathways and deletions investigated in the current study. a The three main sugar signalling pathways in S. cerevisiae, adapted from [39]. The Snf3p/Rgt2p pathway (green) handles expression of hexose transporters in response to extracellular glucose. The SNF1/Mig1p pathway (red) handles expression of genes related to alternative (non-glucose) carbon sources in response to intracellular phosphorylated glucose. The cAMP/PKA pathway (blue) handles e.g. cellular growth, homeostasis and stress response. b Detailed schematic map of the cAMP/PKA pathway with the genes that were deleted in the current study marked with a red cross. Note that two of the three genes (IRA2, HOG1) are closely related to the pathway, whereas the third one (ISU1) is located in the mitochondria and seemingly unrelated to the cAMP/PKA pathway. b was adapted from [46, 47, 56, 63, 81,82,83,84,85]. Solid arrows represent reactions/transport and dashed arrows represent induction (arrowhead) or repression (hammerhead)

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