Fig. 1
a Biosynthetic pathway of glycyrrhetinic acid constructed in S. cerevisiae. IPP: isopentenyl pyrophosphate; DMAPP: dimethylallyl pyrophosphate; GPP: geranyl diphosphate; FPP: farnesyl diphosphate; GGPP: geranylgeranyl pyrophosphate; ERG10: acetyl-CoA C-acetyltransferase; ERG13: hydroxymethylglutaryl-CoA synthase; tHMG1: truncated 3-hydroxy-3-methylglutaryl-CoA reductase 1; ERG12: mevalonate kinase; ERG8: phosphomevalonate kinase; ERG19: diphosphomevalonate decarboxylase; IDI1: dimethylallyl diphosphate isomerase; ERG20: Farnesyl pyrophosphate synthetase; ERG9: squalene synthase; ERG1: squalene epoxidase; β-AS: β-amyrin synthase; AtCPR1: cytochrome P450 reductase from Arabidopsis thaliana; CYP88D6: β-amyrin 11-oxidase; CYP72A154: 11-oxo-beta-amyrin 30-oxidase; b Biosynthetic pathway of ergosterol in S. cerevisiae. BTS1: arnesyltranstransferase; ERG7: lanosterol synthase; ERG11: sterol 14-demethylase; ERG24delta(14)-sterol reductase; ERG25: methylsterol monooxygenase; ERG26: sterol-4-alpha-carboxylate 3-dehydrogenase; ERG27: 3-keto-steroid reductase; ERG28: ergosterol biosynthesis 28; ERG2: C-8 sterol isomerase; ERG3: C-5 sterol desaturase; ERG4: delta(24(24(1)))-sterol reductase; ERG5: C-22 sterol desaturase; ERG6: sterol 24-C-methyltransferase