n | R1 | R2 | Abs.Config.a | Yield (%) | ee (%) | Time (h) |
---|---|---|---|---|---|---|
1 | Ph | CH3 | (R)-1b | 88 (93)b | >99 (> 99) | 4.5 (10) |
2 | Ph-p-CH3 | CH3 | (R)-2b | 79 (89) | >99 (> 99) | 4 (9) |
3 | Ph-p-OCH3 | CH3 | (R)-3b | 45 (51) | >99 (> 99) | 4 (10) |
4 | Ph-p-Br | CH3 | (R)-7b | 81 (90) | >99 (> 99) | 4 (10) |
5 | Ph-p-Cl | CH3 | (R)-6b | 85 (93) | >99 (> 99) | 4 (10) |
6 | Ph-o-Cl | CH3 | (R)-4b | 20 (17) | >99 (> 99) | 4 (10) |
7 | Ph-m-Cl | CH3 | (R)-5b | 25 (28) | >99 (> 99) | 4 (10) |
8 | Ph | CH2OH | (S)-8b | 14 (13) | >99 (> 99) | 4 (8) |
9 | CH3(CH2)2 | CH3 | (R)-9b | 60 (34) | 94 (86) | 3 (8) |
10 | CH3(CH2)3 | CH3 | (R)-10b | 56 (27) | 91 (73) | 3 (8) |
11 | CH3(CH2)4 | CH3 | (R)-11b | 53 (22) | 89 (68) | 3 (8) |
12 | CH3(CH2)5 | CH3 | (R)-12b | 43 (19) | 85 (65) | 3 (8) |
13 | CH3COO | O-CH3 | (R)-13b | 55 (35) | 97 (83) | 5 (12) |
14 | CCl3COCH2 | O-CH2CH3 | (R)-14b | 52 (26) | 90 (77) | 5 (12) |
15 | Ph-CO(CH2)2 | O-CH3 | (R)-15b | 64 (40) | 95 (80) | 5 (12) |