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Fig. 1 | Microbial Cell Factories

Fig. 1

From: In vivo continuous evolution of metabolic pathways for chemical production

Fig. 1

Illustration of in vivo continuous evolution. a General concept of in vivo continuous evolution as an uninterrupted Darwinian evolution occurs for an extended period of time in continuous culturing system. 3 major aspects, in vivo genotype diversification, fitness-coupled selection pressure and environment maintaining continuous culture are well integrated into a system. The mutation occurs endogenously and along with proliferation. b The conceptual difference between in vitro continuous evolution, in vivo evolution and in vivo continuous evolution. I represents in vivo continuous evolution which genotype diversification, natural mutation and selection are integrated. This process occurs as a smooth process without distinguishable plateaus as in in vitro continuous evolution; II represents in vitro continuous evolution dividing into genotype diversification and selection; while III represents in vivo evolution showing a process in which mutation accumulates to form a desired strain

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