Fig. 6

Multimodular optimization to further improve triterpenoid production. a Triterpenoid production by strains in which the CYP/CRP, MVA and redox cofactor supply modules were optimized in combination. b Triterpenoid production by strains in which the CYP/CPR, MVA and acetyl-CoA generation modules were optimized in combination. The light orange background represents strains generated from YLJCC53, and the reseda background represents strains generated from YLJCC56. Red, yellow, green and blue blocks in the first column of the gene forms represent the CYP/CPR, MVA, redox cofactor supply, and acetyl-CoA generation modules, respectively. Asterisk represents the strain exhibiting the highest total triterpenoid production in this study