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Fig. 1 | Microbial Cell Factories

Fig. 1

From: High-titer production of 13R-manoyl oxide in metabolically engineered Saccharomyces cerevisiae

Fig. 1

Schematic overview of the 13R-MO synthesis pathway in S. cerevisiae. Heterologous genes are marked in purple, native MVA pathway genes are marked in orange, overexpressed genes are marked in red are, and ERG9 was downregulated as shown in kermesinus. The Bts1p and Erg20F96Cp fusion protein is indicated in green. Acetyl-CoA acetyl coenzyme A, HMG-CoA 3-hydroxy-3-methylglutaryl-CoA, tHMG1 truncated HMG-CoA reductase gene, IPP isopentenyl pyrophosphate, DMAPP dimethylallyl pyrophosphate, ERG20 farnesyl diphosphate synthetase gene, FPP farnesyl diphosphate synthetase, FOH farnesol, ERG9 squalene synthetase gene, GGPP geranylgeranyl diphosphate, GGOH geranylgeraniol

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