Fig. 4

Structural model of yeast transcriptional factors that enable selective import/export of transcriptional factors across the nuclear membrane. a ScYap1 3-D structure contains the N-terminal nuclear import (NLS) signal that could be recognized by importin Pse1, and the C-terminal cysteine-rich domain (CRD) that sequestrates the leucine zipper nuclear export signal (ZIP-NES). Transcriptional activation domain is also indicated. b Structural model for ScYap1 and ScSkn7 predicted by bioinformatics software I-TASSER. C-score is a confidence score for estimating the quality of predicted models by I-TASSER [76]; a C-score of higher value signifies a model with a high confidence and vice versa