Engineering of leucine-responsive regulatory protein improves spiramycin and bitespiramycin biosynthesis

Table 3 Differentially expressed genes between the ΔSSP_Lrp-SP strain and S. spiramyceticus 1941

ID	P value	GO term	Direction of change	Fold change
comp4553	0.005	Acyl transferase; macrolide antibiotics biosynthetic pathway	Up	Infinity
comp8771	0.025	Acyl-CoA thioesterase; acyl-CoA metabolic process	Up	Infinity
comp9112	0.029	Aspartic acid 1- decarboxylase	Up	Infinity
comp4959	0.028	TPP-dependent pyruvate dehydrogenase	Up	4.6
comp5288	0.005	Sigma24 family factor	Up	3.6
comp1450	0.044	Hydrolase; isoprenoid biosynthesis pathway	Up	2.5
comp1000	0.045	Ribosomal protein S8	Down	Infinity
comp7405	0.023	Ribosomal protein S7	Down	Infinity
comp10453	0.029	Cytochrome P450, sesquiterpenoid and triterpenoid biosynthesis	Down	Infinity
comp4083	0.023	Glutamine synthetase	Down	Infinity
comp9736	0.043	Glutamate synthase	Down	Infinity
comp1697	0.046	DNA-binding transcriptional regulator, AcrR family	Down	5.1

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