Fig. 7From: Growth-dependent recombinant product formation kinetics can be reproduced through engineering of glucose transport and is prone to phenotypic heterogeneitya Grid used for performing “physiological” fingerprinting. b Correlation between GFP production at the single-cell level and global production (orange shaded area corresponds to typical intracellular abundance for native proteins in E. coli). c Principal component analysis; the PCA plane represents the variability of strains regarding their two first principal components. PCA was performed on flow cytometry fingerprinting data. For this purpose, FL-1 versus. FSC cytogram were used for each mutant. Therefore, PCA gathers both morphological (FSC/filamentation) and physiological (FL-1/GFP accumulation) parametersBack to article page