Table 3 S. lividans TK24 genes with (partially) known function with significantly higher expression in a CelA-producing strain compared to an empty plasmid-containing strain in early exponential phase (Benjamini–Hochberg FDR 0.05), but of which expression can not solely be contributed to CelA production
From: Transcriptomic and fluxomic changes in Streptomyces lividans producing heterologous protein
Locus | Function | Expression [TPM] | p-value | |||
|---|---|---|---|---|---|---|
SLIV | SCO | Ref. | CelA | log2(FC) | ||
07685 | 6091 | Integral membrane protein | 30 | 70 | 1.24 | 2.4e−03 |
22330 | 3073 | Urocanate hydratase | 4 | 37 | 3.14 | 5.3e−07 |
12430 | 5190 | DNA-binding protein | 35 | 165 | 2.24 | 1.5e−04 |
29930 | 1559 | Methionine import ATP-binding protein MetN | 26 | 75 | 1.52 | 2.2e−03 |
29940 | 1557 | Lipoprotein | 130 | 384 | 1.56 | 6.0e−05 |
01630 | 7536 | Integral membrane protein | 34 | 164 | 2.28 | 1.4e−09 |
09290 | 5863 | Sensor protein CutS | 11 | 37 | 1.82 | 2.7e−03 |
11255 | 5450 | ABC transporter | 2 | 18 | 3.15 | 7.7e−05 |
12070 | 5259 | Permease | 12 | 54 | 2.17 | 6.3e−04 |
12810 | 5114 | ABC transporter integral membrane protein BldKC | 43 | 125 | 1.52 | 4.5e−04 |
12815 | 5113 | ABC transporter lipoprotein BldKB | 168 | 314 | 0.90 | 1.7e−03 |
13790 | 4917 | Purine nucleoside phosphorylase | 5 | 64 | 3.70 | 3.6e−06 |
13805 | 4914 | Deoxyribose-phosphate aldolase | 7 | 69 | 3.24 | 1.1e−06 |
13870 | 4901 | Adenosine deaminase 1 | 11 | 49 | 2.16 | 3.9e−04 |
16725 | 4334 | Integral membrane protein | 8 | 29 | 1.95 | 3.5e−03 |
16965 | 4286 | Solute-binding protein | 12 | 43 | 1.90 | 1.6e−03 |
17390 | 4198 | DNA-binding protein | 170 | 508 | 1.58 | 1.1e−04 |
18135 | 4054 | Integral membrane protein | 24 | 75 | 1.65 | 2.9e−03 |
19300 | 3800 | Acyl-CoA dehydrogenase | 9 | 56 | 2.67 | 2.6e−07 |
21345 | 3289 | Large membrane protein | 12 | 49 | 2.04 | 3.0e−03 |
22130 | 3111 | ABC transport system ATP-binding protein | 37 | 122 | 1.74 | 2.9e−04 |
22135 | 3110 | ABC transport system integral membrane protein | 21 | 71 | 1.78 | 7.6e−06 |
22235 | 3090 | ABC transporter | 55 | 149 | 1.45 | 1.6e−05 |
22240 | 3089 | ABC transporter ATP-binding protein | 87 | 246 | 1.51 | 9.3e−05 |
23095 | 2920 | Secreted protease | 38 | 116 | 1.60 | 3.0e−05 |
23520 | 2829 | Amino acid ABC transporter transmembrane protein | 9 | 48 | 2.47 | 1.3e−03 |
26890 | 2164 | Integral membrane efflux protein | 31 | 65 | 1.05 | 3.4e−03 |
28875 | 1773 | Alanine dehydrogenase | 4 | 78 | 4.15 | 2.3e−11 |
29635 | 1621 | Glycine/betaine transport ATP-binding protein | 6 | 46 | 2.96 | 1.5e−05 |
29640 | 1620 | Glycine/betaine transport system permease | 3 | 40 | 3.85 | 4.4e−12 |