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Table 3 S. lividans TK24 genes with (partially) known function with significantly higher expression in a CelA-producing strain compared to an empty plasmid-containing strain in early exponential phase (Benjamini–Hochberg FDR 0.05), but of which expression can not solely be contributed to CelA production

From: Transcriptomic and fluxomic changes in Streptomyces lividans producing heterologous protein

Locus Function Expression [TPM] p-value
SLIV SCO Ref. CelA log2(FC)
07685 6091 Integral membrane protein 30 70 1.24 2.4e−03
22330 3073 Urocanate hydratase 4 37 3.14 5.3e−07
12430 5190 DNA-binding protein 35 165 2.24 1.5e−04
29930 1559 Methionine import ATP-binding protein MetN 26 75 1.52 2.2e−03
29940 1557 Lipoprotein 130 384 1.56 6.0e−05
01630 7536 Integral membrane protein 34 164 2.28 1.4e−09
09290 5863 Sensor protein CutS 11 37 1.82 2.7e−03
11255 5450 ABC transporter 2 18 3.15 7.7e−05
12070 5259 Permease 12 54 2.17 6.3e−04
12810 5114 ABC transporter integral membrane protein BldKC 43 125 1.52 4.5e−04
12815 5113 ABC transporter lipoprotein BldKB 168 314 0.90 1.7e−03
13790 4917 Purine nucleoside phosphorylase 5 64 3.70 3.6e−06
13805 4914 Deoxyribose-phosphate aldolase 7 69 3.24 1.1e−06
13870 4901 Adenosine deaminase 1 11 49 2.16 3.9e−04
16725 4334 Integral membrane protein 8 29 1.95 3.5e−03
16965 4286 Solute-binding protein 12 43 1.90 1.6e−03
17390 4198 DNA-binding protein 170 508 1.58 1.1e−04
18135 4054 Integral membrane protein 24 75 1.65 2.9e−03
19300 3800 Acyl-CoA dehydrogenase 9 56 2.67 2.6e−07
21345 3289 Large membrane protein 12 49 2.04 3.0e−03
22130 3111 ABC transport system ATP-binding protein 37 122 1.74 2.9e−04
22135 3110 ABC transport system integral membrane protein 21 71 1.78 7.6e−06
22235 3090 ABC transporter 55 149 1.45 1.6e−05
22240 3089 ABC transporter ATP-binding protein 87 246 1.51 9.3e−05
23095 2920 Secreted protease 38 116 1.60 3.0e−05
23520 2829 Amino acid ABC transporter transmembrane protein 9 48 2.47 1.3e−03
26890 2164 Integral membrane efflux protein 31 65 1.05 3.4e−03
28875 1773 Alanine dehydrogenase 4 78 4.15 2.3e−11
29635 1621 Glycine/betaine transport ATP-binding protein 6 46 2.96 1.5e−05
29640 1620 Glycine/betaine transport system permease 3 40 3.85 4.4e−12
  1. A clustering algorithm was used for grouping nearby genes with similar expression patterns. When present, the corresponding ortholog of the model organism S. coelicolor is given