From: Transcriptomic and fluxomic changes in Streptomyces lividans producing heterologous protein
Locus | Function | Expression [TPM] | p-value | |||
---|---|---|---|---|---|---|
SLIV | SCO | Ref. | CelA | log2(FC) | ||
01755 | 7511 | Glyceraldehyde-3-phosphate dehydrogenase Gap3 | 52 | 323 | 2.65 | 2.8e−08 |
05195 | 6663 | Transketolase | 25 | 207 | 3.06 | 4.0e−13 |
05200 | 6662 | Transaldolase 1 | 53 | 158 | 1.57 | 3.6e−04 |
05205 | 6661 | Glucose-6-phosphate 1-dehydrogenase | 40 | 110 | 1.46 | 1.9e−04 |
05215 | 6659 | Glucose-6-phosphate isomerase 1 | 64 | 134 | 1.06 | 2.4e−03 |
05220 | 6658 | 6-phosphogluconate dehydrogenase | 144 | 221 | 0.62 | 4.0e−02* |
05225 | 6657 | Membrane-associated oxidoreductase | 26 | 33 | 0.32 | 3.9e−01* |
18590 | 3946 | CydB cytochrome d ubiquinol oxidase, subunit II | 127 | 204 | 0.68 | 2.4e−02* |
18595 | 3945 | CydA cytochrome oxidase subunit I | 250 | 892 | 1.83 | 2.0e−09 |
33310 | 0924 | Cytochrome B subunit | 45 | 273 | 2.59 | 5.9e−09 |
33315 | 0923 | Fumarate dehydrogenase | 17 | 96 | 2.50 | 3.9e−09 |
33320 | 0922 | Fumarate dehydrogenase | 26 | 78 | 1.59 | 3.1e−03 |
36805 | 0219 | Respiratory nitrate reductase, gamma subunit | 0 | 28 | Inf | 5.2e−07 |
36810 | 0218 | Nitrate reductase subunit delta | 0 | 36 | Inf | 2.0e−08 |
36815 | 0217 | Nitrate reductase beta chain | 0 | 111 | 8.23 | 1.0e−28 |
36820 | 0216 | Nitrate reductase alpha subunit | 2 | 192 | 6.86 | 3.5e−49 |
36825 | 0215 | \(\hbox {Nitroreductase}^{\dagger }\) | 1 | 82 | 7.14 | 4.0e−15 |
36830 | 0214 | Pyridoxamine 5′-phosphate \(\hbox {oxidase}^{\dagger }\) | 4 | 58 | 4.03 | 1.4e−04 |
36835 | 0213 | Nitrate/nitrite transporter | 3 | 114 | 5.46 | 1.0e−20 |
36845 | 0211 | Two-component sensor | 2 | 73 | 5.21 | 1.4e−08 |
36850 | 0209 | Cystathionine \(\beta \)-\(\hbox {syntase}^{\dagger }\) | 1 | 109 | 6.97 | 1.4e−20 |
36855 | 0208 | Pyruvate, phosphate dikinase | 1 | 65 | 5.90 | 5.4e−24 |
36865 | 0206 | Putative pyruvate formate-lyase | 0 | 74 | Inf | 3.1e−05 |
36867 |  | Putative pyruvate formate-lyase-activating protein, N-terminal fragment, putative pseudogene | 0 | 74 | Inf | 7.7e−06 |
36875 | 0204 | Transcriptional regulatory protein OsdR | 16 | 391 | 4.60 | 3.1e−25 |
36880 | 0203 | Two-component sensor OsdK | 23 | 56 | 1.30 | 4.2e−03* |
36890 | 0201 | Thiosulfate dehydrogenase (quinone)\(^{\dagger }\) | 1 | 464 | 8.97 | 3.5e−37 |
36895 | 0200 | Universal stress \(\hbox {protein}^{\dagger }\) | 0 | 317 | Inf | 2.5e−04 |
36900 | 0199 | Alcohol dehydrogenase | 1 | 214 | 8.55 | 9.3e−26 |
36905 | 0198 | Universal stress \(\hbox {protein}^{\dagger }\) | 1 | 72 | 6.16 | 2.9e−11 |
36910 | 0197 | Pyridoxamine 5′-phosphate \(\hbox {oxidase}^{\dagger }\) | 6 | 97 | 4.07 | 3.1e−09 |
37035 | 0181 | Universal stress \(\hbox {protein}^{\dagger }\) | 2 | 175 | 6.76 | 4.0e−22 |
37040 | 0180 | Universal stress \(\hbox {protein}^{\dagger }\) | 0 | 69 | Inf | 2.7e−14 |
37045 | 0179 | Zinc-containing dehydrogenase | 4 | 293 | 6.37 | 6.9e−32 |
37050 | 0178 | Universal stress \(\hbox {protein}^{\dagger }\) | 8 | 28 | 1.72 | 1.2e−01 |
37060 | 0177 | Membrane protein | 2 | 112 | 6.22 | 2.5e−12 |
37070 | 0174 | pyridoxamine 5′-phosphate \(\hbox {oxidase}^{\dagger }\) | 1 | 232 | 8.50 | 6.0e−32 |
37075 | 0173 | OsmC regulator of disulfide bond formation redox \(\hbox {protein}^{\dagger }\) | 7 | 78 | 3.48 | 2.8e−06 |
37080 | 0172 | Universal stress \(\hbox {protein}^{\dagger }\) | 3 | 17 | 2.76 | 1.1e−01 |
37085 | 0171 | Nicotinate phosphoribosyltransferase | 0 | 56 | Inf | 3.5e−17 |
37095 | 0169 | Cystathionine \(\beta \)-\(\hbox {synthase}^{\dagger }\) | 10 | 398 | 5.29 | 4.0e−30 |
37100 | 0168 | Regulator protein | 10 | 625 | 5.94 | 5.1e−33 |
37105 | 0167 | Universal stress \(\hbox {protein}^{\dagger }\) | 4 | 297 | 6.35 | 8.5e−31 |
37130 | 0162 | \(\hbox {Nitroreductase}^{\dagger }\) | 0 | 91 | 8.28 | 3.5e−17 |
37090 | 0170 | Cystathionine \(\beta \)-\(\hbox {synthase}^{\dagger }\) | 6 | 252 | 5.44 | 1.2e−21 |