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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Identification of sesquiterpene synthases from the Basidiomycota Coniophora puteana for the efficient and highly selective β-copaene and cubebol production in E. coli

Fig. 1

Design of the synthetic operons for an increased precursor supply and efficient STP production. Enzymatic bottlenecks within the upstream non-mevalonate (MEP) pathway (dxs and idi) as well as the heterologous STPS genes (Copu2 and Copu3) are combined in a single synthetic operon. The integration of an additional geranylgeranyl diphosphate synthase (crtE) allowed to study a potential function as diterpene synthases. A constitutive promoter (P) regulates the pathways

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