Fig. 6

Data driven model for time dependent analysis of IB a titer, b size and c purity of strain 2 using a reduced DoE design (Fig. 1b). Trends are given with differences of the lowest process value. Very similar behavior to strain 1 can be found, showing highest purity, size and titer at values for low T and pH. Higher titers are produced using this strain resulting in boosted purities compared to strain 1. The analyzed size similar to strain 1