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Table 1 LogP, Papp and UR values for troxerutin and its propionyl derivatives in Caco-2 cell monolayers

From: Biocatalytic synthesis of acylated derivatives of troxerutin: their bioavailability and antioxidant properties in vitro

Compound LogP Papp AP–BL (×10−6 cm/s) Papp BL–AP (×10−6 cm/s) UR1
Troxerutin − 2.04 ± 0.10 0.34 ± 0.05 d 0.35 ± 0.03 d 0.97 ± 0.07
TME − 0.75 ± 0.08 0.99 ± 0.12 c 1.05 ± 0.12 c 0.94 ± 0.18
TDE 1.51 ± 0.05 1.54 ± 0.17 b 1.53 ± 0.21 b 1.00 ± 0.09
Rutin − 0.58 ± 0.13 0.06 ± 0.01 e 0.06 ± 0.02 e 1.00 ± 0.05
Propranolol 2 48.90 ± 3.30 a 44.05 ± 2.98 a 1.11 ± 4.90
Furosemide 2 0.85 ± 0.15 c 0.86 ± 0.11 c 0.99 ± 0.13
  1. Experiments were performed in triplicate, and data are presented as the mean ± SD. Values with different letters (a, b, c, d, e) in an assay are significantly different one from another (P < 0.05) in multiple-range analysis
  2. 1UR = Papp AP–BL/Papp BL–AP
  3. 2Not measured