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Table 1 Growth performance and intracellular Kar2/Bip level of P. pastoris X-33 carrying the aox1 promoter-controlled IP gene during batch growth in a 2 L bioreactor with different initial glycerol concentrations

From: Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch cultures of secretory insulin precursor producing Pichia pastoris

Glycerol (g/L)

30

60

95

125

µmax (1/h)

0.26

0.19

0.18

0.18

Osmolarity (Osmol/kg)

0.8

1.4

1.9

2.5

Relative Kar2/Bip abundance

114

123

100

116