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Fig. 3 | Microbial Cell Factories

Fig. 3

From: Spatial organization of enzymes to enhance synthetic pathways in microbial chassis: a systematic review

Fig. 3

Typical scaffolding approaches based on genome editing tools. a ZFP-based method using synthesized plasmid DNA containing binding motifs of ZFPs as medium molecule, enzymes are fused with zinc finger domains. b TALE based approach using DNA containing multiple binding motifs of TALEs as medium molecule. Enzymes are fused with artificial designed and constructed TALE domains with high DNA-binding affinity and specificity. c CRISPR-Cas9 system and its potential on spatial organization of enzymes

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