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Table 3 The DCW, l-lysine production, by-product accumulation, maximal specific growth rate (μmax.), maximal specific production rate of l-lysine (qLys, max.) and glucose conversion efficiency (α) of modified glutamate dehydrogenase C. glutamicum strains

From: Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum

C. glutamicum strains

Concentration of (g L−1)

DCW (g L−1)

μmax (h−1)

qLys, max. (g g−1 h−1)

α (%)

l-Lys

l-Asp

l-Glu

α-KG

OAA

JL-69

21.44 ± 1.93

< 0.01

1.08 ± 0.13

0.77 ± 0.21

1.13 ± 0.14

9.75 ± 1.35

0.20

0.47 ± 0.08

53.60

JL-69PdapA-L1 gdh

10.75 ± 1.14

< 0.01

0.22 ± 0.06

1.38 ± 0.12

1.22 ± 0.17

9.82 ± 1.01

0.22

0.21 ± 0.03

26.88

JL-69Ptac gdh

22.27 ± 1.29

< 0.01

2.05 ± 0.18

0.65 ± 0.13

0.96 ± 0.08

9.24 ± 1.35

0.20

0.48 ± 0.08

55.68

JL-69Ptac-M gdh

23.86 ± 2.16

0.21 ± 0.03

3.38 ± 0.42

0.41 ± 0.10

0.32 ± 0.05

7.83 ± 1.12

0.19

0.63 ± 0.11

59.65

JL-69Ptuf gdh

16.03 ± 1.32

< 0.01

1.82 ± 0.07

0.18 ± 0.03

< 0.01

5.36 ± 1.04

0.14

0.81 ± 0.17

40.08

JL-69Psod gdh

20.16 ± 2.08

< 0.01

1.27 ± 0.10

0.24 ± 0.09

< 0.01

6.78 ± 0.72

0.16

0.70 ± 0.08

50.40

  1. All data are meaning values of three determinations of three independent experiments with ± SD
  2. l-Lys l-lysine, l-Asp l-aspartate, l-Glu l-glutamate; α-KG α-ketoglutarate, OAA oxaloacetate