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Table 1 The time course of the transformation of progesterone, pregnenolone and 16-dehydropregnenolone by P. lanosocoeruleum

From: Metabolic fate of pregnene-based steroids in the lactonization pathway of multifunctional strain Penicillium lanosocoeruleum

Substrate

Rt (min)

Steroidal compounds identified in the mixture (%)a

Time of transformation (h)

9

24

48

72

96

Progesterone (1)

6.82

Progesterone (1)

67

18

6

2

 

4.76

Testosterone (2)b

26

36

3

 

4.54

Androstenedione (3)b

7

10

5

2

 

8.69

Testololactone (4)

36

85

88

 

Pregnenolone (5)

5.57

Pregnenolone (5)

75

54

34

28

19

6.82

Progesterone (1)b

5

2

3

4

2

4.76

Testosterone (2)b

11

13

5

6

4.54

Androstenedione (3)b

4

3

8

3

3

3.51

DHEA (6)b

3

4

2

6.91

3β-Hydroxy-17a-oxa-d-homo-androst-5-en-17-one (7)b

2

6

8

5

8.69

Testololactone (4)

2

19

41

44

31

16-Dehydropregnenolone (8)

5.22

16-Dehydropregnenolone (8)

84

12

 

6.91

3β-Hydroxy-17a-oxa-d-homo-androst-5-en-17-one (7)

10

75

81

70

 

8.69

Testololactone (4)

5

13

18

30

 
  1. aDetermined by GC analysis of the crude chloroform extracts
  2. bIdentified in GC and TLC on the basis of standard