Optimization of ʟ-ornithine production in recombinant Corynebacterium glutamicum S9114 by cg3035 overexpression and manipulating the central metabolic pathway

Table 3 Comparison of other C. glutamicum strains engineered for ʟ-ornithine production

Strains (C. glutamicum)	ʟ-Ornithine titer (g/L)	ʟ-Ornithine yield (g/g glucose)	Cultivation	Modulations	References
SO16	32.3	0.395	Shake flask; batch	Deletion of argF, ncgl1221, argR, and putP; attenuation of odhA, proB, pta, cat and ncgl2228; overexpression of lysE, gdh, cg3035, pfkA, pyk, tkt, and argCJBD	This study
YW06 (pSY223)	51.5	0.240	Bioreactor; fed-batch	Deletion of argF, argR, and proB; Reinforcement of the PPP pathway flux; The use of a feedback-resistant enzyme	[12]
ORN6	20.96^a	0.524	Shake flask; batch	Deletion of argF, argR, and argG; overexpression of argB^M; attenuation of pgi.	[10]
SJC8039 ∆ncgl0281∆ncgl2582∆ncgl2053	14^a	ND	Shake flask; batch	Deletion of argF, argR, and proB; Blocking gluconate biosynthesis	[11]
∆APE6937R42	24.1	0.298	Bioreactor; batch	Deletion of argF, argR, and proB; Adaptive evolution in presence of ʟ-ornithine	[13]
1006∆argR-argJ	31.6	0.396	Shake flask; batch	Deletion of argR; overexpression of argJ.	[31]

^aThese values were not described in the main text of the original reference and thus estimated from the figure or graph

ISSN: 1475-2859